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Tocris™ VCP 171
Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist
227.86€ - 881.19€
Specifications
| Chemical Name or Material | [2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone |
|---|---|
| CAS | 1018830-99-3 |
| Target | Adenosine A1 Receptor Modulators |
| Molecular Formula | C18H12F3NOS |
| Purity | 0.98 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18779916
|
Tocris™
6261/10 |
10 mg |
227.86€
10mg |
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|
18759886
|
Tocris™
6261/50 |
50 mg |
881.19€
50mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
VCP 171 is an adenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5.65, binding cooperativity with NECA 0.68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor-mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve-injury model of neuropathic pain.Specifications
| [2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone | |
| Adenosine A1 Receptor Modulators | |
| 0.98 |
| 1018830-99-3 | |
| C18H12F3NOS |
Safety and Handling
Recommended Storage : Store at -20°C