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Tocris™ VCP 171

Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

Brand:  Tocris™ 6261/50

704.95 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.

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Product Code. 18759886

  • 794.00€ / 50mg

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Description

Description

VCP 171 is an adenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5.65, binding cooperativity with NECA 0.68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor-mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve-injury model of neuropathic pain.
Specifications

Specifications

[2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone
50 mg
C18H12F3NOS
1018830-99-3
Adenosine A1 Receptor Modulators
0.98
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