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Tocris Bioscience™ TH 9619 disodium salt
MTHFD2 inhibitor
178.00€ - 626.00€
Specifications
| Chemical Name or Material | Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate |
|---|---|
| Target | Dehydrogenase Inhibitors |
| Molecular Formula | C17H16FN7Na2O7 |
| Purity | 0.98 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18055112
|
Tocris Bioscience™
7719/50 |
50 mg |
626.00€
50mg |
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|
18014022
|
Tocris Bioscience™
7719/10 |
10 mg |
178.00€
10mg |
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Description
TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AmL) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AmL.Specifications
| Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate | |
| Dehydrogenase Inhibitors | |
| C17H16FN7Na2O7 | |
| 0.98 |
Safety and Handling
Recommended Storage : Store at -20°C
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