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Tocris Bioscience™ TH 9619 disodium salt

MTHFD2 inhibitor

Brand:  Tocris Bioscience™ 7719/10

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Product Code. 18014022

  • 178.00€ / 10mg

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Description

Description

TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AmL) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AmL.
Specifications

Specifications

Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate
Dehydrogenase Inhibitors
0.98
10 mg
C17H16FN7Na2O7
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