missing translation for 'onlineSavingsMsg'
Learn More
Learn More
PYR 41, Tocris Bioscience™
Click to view available options
10mg
Description
Cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Blocks ubiquitination and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
Specifications
Specifications
CAS | 418805-02-4 |
Molecular Formula | C17H13N3O7 |
Quantity | 10 mg |
Synonym | pyr-41, pyr 41, pyr41, ubiquitin e1 inhibitor, pyr-41, ethyl 4-4z-4-5-nitrofuran-2-yl methylidene-3,5-dioxopyrazolidin-1-yl benzoate, benzoic acid, 4-4-5-nitro-2-furanyl methylene-3,5-dioxo-1-pyrazolidinyl-, ethyl ester, 4-4-5-nitro-furan-2-ylmethylene-3,5-dioxo-pyrazolidin-1-yl-benzoic acid ethyl ester, 4 4-5-nitro-furan-2-ylmethylene-3,5-dioxo-pyrazolidin-1-yl-benzoic acid ethyl ester |
InChI Key | ARGIPZKQJGFSGQ-LCYFTJDESA-N |
SMILES | CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2 |
IUPAC Name | ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate |
Molecular Weight (g/mol) | 371.305 |
PubChem CID | 5335621 |
Formula Weight | 371.3 |
Show More |
missing translation for 'provideContentCorrection'
missing translation for 'productTitle'