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Thermo Scientific™ MM(PEG)12 Methyl-PEG-Maleimide Reagent

Pegylate sulfhydryls (-SH groups) on proteins (cysteine residues) or assay surfaces using MS(PEG); sulfhydryl-reactive (maleimide), PEG compounds (12 and 24 EG units).

Brand:  Thermo Scientific™ 22711

Product Code. 11821325

  • 488.00€ / 100mg

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Description

Description

Thermo Scientific™ Pierce MM(PEG)12 is a methyl-terminated, polyethylene glycol compound (3 times 12 PEG units) activated with a maleimide group for covalent pegylation of sulfhydryls on proteins (e.g., cysteines) or assay surfaces.

MM(PEG)n is the abbreviation for a set of compounds having polyethylene glycol (PEG) spacers with methyl (—CH3) and sulfhydryl-reactive maleimide groups at opposite ends. The unbranched, hydrophilic, discrete-length molecules have the form Methyl-PEGn-Maleimide, where the subscript “n” denotes 12 or 24 ethylene glycol units. The maleimide is spontaneously reactive with sulfhydryl (—SH) groups, providing for efficient PEGylation of proteins, peptides and other cysteine- or thiol-containing molecules.

Highlights:

  • Maleimide-activated for efficient PEGylation of sulfhydryl groups at pH 6.5-7.5; reaction of maleimide group results in formation of stable, irreversible thioether bonds
  • Fully characterized PEGylation reagents with defined PEG chain lengths; molecules of discrete molecular weight for consistency of performance in protein-modification applications
  • Provided with either 12 or 24 ethylene glycol units, enabling modification procedures to be optimized for a specific application while retaining all the benefits associated with protein PEGylation
  • PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
  • Easy-to-follow instructions increase the likelihood of a successful outcome
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Thiol
Upon receipt store desiccated at 4°C. Product is shipped at ambient temperature.
Maleimide
Powder
Water
Pierce MM(PEG)12
Polyethylene Glycol (PEG), Blocking Groups
12 ethylene glycol units
100 mg
Maleimide Reagent
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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberYL362444 Certificate TypeCertificate of Analysis Date25/01/2024 Catalog Number22711
Lot NumberXH358458 Certificate TypeCertificate of Analysis Date30/08/2022 Catalog Number22711
Lot NumberWG320595 Certificate TypeCertificate of Analysis Date30/07/2021 Catalog Number22711
Lot NumberVE292965 Certificate TypeCertificate of Analysis Date07/05/2020 Catalog Number22711
Lot NumberUA279177 Certificate TypeCertificate of Analysis Date19/01/2019 Catalog Number22711
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Thermo Scientific™ MM(PEG)12 Methyl-PEG-Maleimide Reagent > 12 ethylene oxide units; 100mg

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