missing translation for 'onlineSavingsMsg'
Learn More
Phorbol 12-myristate 13-acetate, >94%, Thermo Scientific Chemicals Product Code.: 15476069

Phorbol 12-myristate 13-acetate, >94%, Thermo Scientific Chemicals

Product Code. 15476069
1 mg
Click to view available options
Quantity:
1 mg
5 mg
10 mg
25 mg
This item is not returnable. View return policy

Product Code. 15476069

Brand: Thermo Scientific Alfa Aesar J63916.M^

Request Bulk or Custom Format

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Activates protein kinase C and promotes skin tumors in mice.

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.

Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 16561-29-8
Molecular Formula C36H56O8
Molecular Weight (g/mol) 616.84
MDL Number MFCD00036736
InChI Key PHEDXBVPIONUQT-RGYGYFBISA-N
Synonym phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate
PubChem CID 27924
ChEBI CHEBI:37537
IUPAC Name (1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,⁶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate
SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O

Specifications

Color White
Quantity 1 mg
Beilstein 2407201
Sensitivity Light sensitive
Merck Index 14,7332
Solubility Information Very soluble in methanol,soluble in DMSO,chloroform,ethanol or acetone,ether,ethyl acetate,DMF or acetonitrile. Insoluble in water.
Formula Weight 616.83
Percent Purity >94%
Physical Form Film or Powder
Chemical Name or Material Phorbol 12-myristate 13-acetate

Certificates

A lot number is required to show results for certificates. To find your lot number on previous orders use our order status area.

5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberM07L017 Certificate TypeCertificate of Analysis Date09/01/2025 Catalog NumberJ63916.#0,J63916.MB,J63916.M^,J63916.MA
Lot NumberY13K055 Certificate TypeCertificate of Analysis Date06/01/2025 Catalog NumberJ63916.#0,J63916.MB,J63916.M^,J63916.MA
Lot NumberY26K037 Certificate TypeCertificate of Analysis Date27/11/2024 Catalog NumberJ63916.#0,J63916.MB,J63916.M^,J63916.MA
Lot NumberX15K030 Certificate TypeCertificate of Analysis Date30/10/2024 Catalog NumberJ63916.#0,J63916.MB,J63916.M^,J63916.MA
Lot NumberU08K014 Certificate TypeCertificate of Analysis Date21/08/2024 Catalog NumberJ63916.#0,J63916.MB,J63916.M^,J63916.MA
compliance-icons compliance-icons compliance-icons
Product Identifier
  • Phorbol 12-myristate 13-acetate
Signal Word
  • Danger
Hazard Category
  • Acute toxicity Category 1
  • Acute toxicity Category 2
  • Carcinogenicity Category 2
  • Serious eye damage/eye irritation Category 1
  • Respiratory sensitiser Category 1
  • Skin corrosion/irritation Category 1 B
  • Skin sensitiser Category 1
Hazard Statement
  • H300-Fatal if swallowed.
  • H310-Fatal in contact with skin.
  • H314-Causes severe skin burns and eye damage.
  • H317-May cause an allergic skin reaction.
  • H318-Causes serious eye damage.
  • H330-Fatal if inhaled.
  • H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H351-Suspected of causing cancer.
Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P284-¢In case of inadequate ventilation! wear respiratory protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.
  • P362+P364-Take off contaminated clothing and wash it before reuse.
Supplemental information
  • MIXTURE LIST-Contains : Tetradecanoyl phorbol acetate

RUO – Research Use Only

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title
Phorbol 12-myristate 13-acetate, >94%, Thermo Scientific Chemicals >

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.