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Phorbol 12-myristate 13-acetate, >94%, Thermo Scientific Chemicals
Description
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
Specifications
Specifications
| Color | White |
| Quantity | 1 mg |
| Beilstein | 2407201 |
| Sensitivity | Light sensitive |
| Merck Index | 14,7332 |
| Solubility Information | Very soluble in methanol,soluble in DMSO,chloroform,ethanol or acetone,ether,ethyl acetate,DMF or acetonitrile. Insoluble in water. |
| Formula Weight | 616.83 |
| Percent Purity | >94% |
| Physical Form | Film or Powder |
| Chemical Name or Material | Phorbol 12-myristate 13-acetate |
Certificates
Certificates
A lot number is required to show results for certificates. To find your lot number on previous orders use our order status area.
| Lot Number | Certificate Type | Date | Catalog Number |
|---|---|---|---|
| M07L017 | Certificate of Analysis | 09/01/2025 | J63916.#0,J63916.MB,J63916.M^,J63916.MA |
| Y13K055 | Certificate of Analysis | 06/01/2025 | J63916.#0,J63916.MB,J63916.M^,J63916.MA |
| Y26K037 | Certificate of Analysis | 27/11/2024 | J63916.#0,J63916.MB,J63916.M^,J63916.MA |
| X15K030 | Certificate of Analysis | 30/10/2024 | J63916.#0,J63916.MB,J63916.M^,J63916.MA |
| U08K014 | Certificate of Analysis | 21/08/2024 | J63916.#0,J63916.MB,J63916.M^,J63916.MA |
Safety and Handling
- Phorbol 12-myristate 13-acetate
- Danger
- Acute toxicity Category 1
- Acute toxicity Category 2
- Carcinogenicity Category 2
- Serious eye damage/eye irritation Category 1
- Respiratory sensitiser Category 1
- Skin corrosion/irritation Category 1 B
- Skin sensitiser Category 1
- H300-Fatal if swallowed.
- H310-Fatal in contact with skin.
- H314-Causes severe skin burns and eye damage.
- H317-May cause an allergic skin reaction.
- H318-Causes serious eye damage.
- H330-Fatal if inhaled.
- H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- H351-Suspected of causing cancer.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P284-¢In case of inadequate ventilation! wear respiratory protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P310-Immediately call a POISON CENTER/doctor/.
- P362+P364-Take off contaminated clothing and wash it before reuse.
- MIXTURE LIST-Contains : Tetradecanoyl phorbol acetate
RUO – Research Use Only
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