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PHLPP2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA531319
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Description
Recommended positive controls: mouse brain. Predicted reactivity: Mouse (96%), Rat (97%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). [UniProt]
Specifications
| PHLPP2 | |
| Polyclonal | |
| Unconjugated | |
| Phlpp2 | |
| AI481772; C130044A18Rik; GTPase activating protein and VPS9 domains 1; KIAA0931; PH domain and leucine rich repeat protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP2; Phlppl; PHLPP-like; PPM3B; protein phosphatase, Mg2+/Mn2+ dependent 3B; RGD1562857 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 23035, 244650 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Western Blot | |
| 1 mg/mL | |
| PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q6ZVD8, Q8BXA7 | |
| Phlpp2 | |
| Recombinant fragment corresponding to a region within amino acids 13 and 234 of Human PHLPP2 | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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