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Tocris Bioscience™ PF 5274857 hydrochloride

High affinity and selective Smoothened (Smo) receptor antagonist

Brand:  Tocris Bioscience™ 5262/50

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Product Code. 18734729

  • 885.00€ / 50mg

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Description

Description

PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

>98%
PF 5274857 hydrochloride
PF 5274857 hydrochloride
50 mg
473.42
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