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Tocris Bioscience™ GSK 626616
Potent and selective DYRK inhibitor; orally bioavailable.
Specifications
Chemical Name or Material | (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone |
---|---|
CAS | 1025821-33-3 |
Molecular Formula | C18H10Cl2N4OS |
Formula Weight | 401.27 |
Purity | 98% |
Description
- Potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2)
- Exhibits ∼20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened
- Enhances number of CFU-E stimulated by Epo from human marrow
- Increases hemoglobin levels in anemic mice
- Orally bioavailable
Specifications
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone | |
C18H10Cl2N4OS | |
98% |
1025821-33-3 | |
401.27 |
Safety and Handling
Recommended Storage : Store at 4°C