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  6. Thermo Scientific™ EZ-Link™ Maleimide-PEG4-DBCO
  7. 17631586

Thermo Scientific™ EZ-Link™ Maleimide-PEG4-DBCO

A sulfhydryl reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications. The thiol/sulfhdryl reactive maleimide can be used to label a variety of thiol containing moieties such as free cystines in proteins, peptides, or other (bio)molecules.

Brand:  Thermo Scientific™ C20044

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Product Code. 17631586

  • 277.00€ / Pack of 10
Estimated Shipment: 17-01-2025
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Description

Description

  • A sulfhydryl reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications
  • The thiol/sulfhdryl reactive maleimide can be used to label a variety of thiol containing moieties such as free cystines in proteins, peptides, or other (bio)molecules
  • Once a protein or (bio)molecule is DBCO labeled, it can undergo a copper-free azide-alkyne cycloaddition reaction to form a stable triazole linkage with an azide labeled coupling partner
  • Can be used to create diverse conjugates with the biorthogonal coupling between an alkyne and azide (supplied separately)
  • The coupling or crosslinking procedure is typically done in two steps:
    • First, a protein or thiol containing molecule is labeled with a DBCO group and excess crosslinker is removed
    • Second, an azide containing moiety (prepared independently) is introduced into the same system as the DBCO moiety
    • Labeling occurs under biological conditions without the introduction of any additional reagents such as a copper catalyst
  • Reagent readily dissolves in water-miscible solvents for dilution into aqueous reaction mixtures
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Azide-Sulfhydryl
Maleimide-PEG4-DBCO
Yes
Upon receipt store desiccated at -20°C.
Wet Ice
Chemical Labeling
Maleimide, DBCO
Powder
DMF, DMSO
No
No
647.74
29.7 Å
Not determined
EZ-Link™ No-Weigh™
Heterobifunctional
Medium (10 to 30 Å)
10 x 1 mg
Standard, Single-use
Crosslinker
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