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  8. Benzenesulfonamide, 98+%, Thermo Scientific Chemicals

Benzenesulfonamide, 98+%, Thermo Scientific Chemicals

Product Code. 11494243
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Description

Biospecific adsorption of carbonic anhydrase to self-assembled monolayers of alkanethiolates that present benzenesulfonamide groups on gold. Biospecific binding of carbonic anhydrase to mixed sams presenting benzenesulfonamide ligands led to a model system for studying lateral steric effects. Benzenesulfonamide modifications at c-7 of ciprofloxacin change its primary target instreptococcus pneumoniae from topoisomerase iv to gyrase. Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
The presence of the benzenesulfonylamido (BS) groups shifted the activity of classic antimicrobial fluoroquinolones from being more active against Gram-negative to Gram-positive strains. Biospecific adsorption of carbonic anhydrase to self-assembled monolayers of alkanethiolates that present benzenesulfonamide groups on gold. Biospecific binding of carbonic anhydrase to mixed sams presenting benzenesulfonamide ligands led to a model system for studying lateral steric effects. In engineering the specificity of antibacterial fluoroquinolones, benzenesulfonamide modifications at c-7 of ciprofloxacin change its primary target instreptococcus pneumoniae from topoisomerase iv to gyrase. Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.

Solubility
Soluble in methanol (25 mg/ml), and water (4.3 mg/ml at 16°C).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 98-10-2
Molecular Formula C6H7NO2S
Molecular Weight (g/mol) 157.187
MDL Number MFCD00007930
InChI Key KHBQMWCZKVMBLN-UHFFFAOYSA-N
Synonym benzenesulphonamide, benzosulfonamide, benzolsulfonamide, phenyl sulfonamide, benzene sulfonamide, phenylsulfonamide, m and b 7973, chembl27601, benzolsulfonamid, benzensulfonamide
PubChem CID 7370
IUPAC Name benzenesulfonamide
SMILES C1=CC=C(C=C1)S(=O)(=O)N

Specifications

Melting Point 151°C to 154°C
Flash Point 250°C (482°F)
Odor Odorless
Quantity 250 g
Beilstein 1100566
Solubility Information Soluble in methanol (25mg/ml),and water (4.3mg/ml at 16°C).
Formula Weight 157.19
Percent Purity ≥98%
Chemical Name or Material Benzenesulfonamide

RUO – Research Use Only

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