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Tocris Bioscience™ (5Z)-7-Oxozeaenol
Potent and selective TAK1 MAPKKK inhibitor
Brand: Tocris Bioscience™ 3604/1
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Description
(5Z)-7-Oxozeaenol is a resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-κB (IC50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.
Specifications
| >99% | |
| (5Z)-7-Oxozeaenol | |
| (5Z)-7-Oxozeaenol |
| 1 mg | |
| 362.37 |
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Product Title
Tocris Bioscience™ (5Z)-7-Oxozeaenol > 1mg
For Research Use Only
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