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VU 0360172 hydrochloride, Tocris Bioscience™

Product Code. 30001491
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Positive allosteric modulator of mGlu5 receptors

Positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

Chemical Identifiers

CAS 1309976-62-2
Molecular Formula C18H16ClFN2O
Molecular Weight (g/mol) 330.787
InChI Key NBGAPTWZQXSEAA-UHFFFAOYSA-N
Synonym vu 0360172 hydrochloride, n-cyclobutyl-6-2-3-fluorophenyl ethynyl-3-pyridinecarboxamide hydrochloride, n-cyclobutyl-6-2-3-fluorophenyl ethynyl pyridine-3-carboxamide hydrochloride
PubChem CID 53384852
IUPAC Name N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]pyridine-3-carboxamide;hydrochloride
SMILES C1CC(C1)NC(=O)C2=CN=C(C=C2)C#CC3=CC(=CC=C3)F.Cl

Specifications

Quantity 50 mg
Formula Weight 330.78
Percent Purity >98%
Chemical Name or Material VU 0360172 hydrochloride
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