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U0126, Tocris Bioscience™

Product Code. 30001208
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Quantity:
5 mg
25 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent, selective inhibitor of MEK1 and 2

Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Brain penetrant. Helps maintain human pluripotent stem cells in undifferentiated state.

Negative Control also available.

Chemical Identifiers

CAS 109511-58-2
Molecular Formula C18H16N6S2
Molecular Weight (g/mol) 380.49
MDL Number MFCD01861186
InChI Key DVEXZJFMOKTQEZ-JYFOCSDGSA-N
Synonym 1,4-diamino-2,3-dicyano-1,4-bis o-aminophenylmercapto butadiene, unii-8027p94hll, 2z,3z-bis amino 2-aminophenyl sulfanyl methylidene butanedinitrile, succinonitrile, bis amino o-aminophenylthio methylene, butanedinitrile, bis amino 2-aminophenyl thio methylene, 2z,3z-bis amino 2-aminophenyl sulfanyl methylene succinonitrile, 2z,3z-2,3-bis amino-2-aminophenyl sulfanyl-methylene butanedinitrile, biomolki_000002, biomolki2_000012
PubChem CID 3006531
ChEBI CHEBI:64208
IUPAC Name (2Z,3Z)-bis({amino[(2-aminophenyl)sulfanyl]methylidene})butanedinitrile
SMILES N\C(SC1=CC=CC=C1N)=C(\C#N)/C(/C#N)=C(\N)SC1=CC=CC=C1N

Specifications

Quantity 5 mg
Formula Weight 380.48
Percent Purity >98%
Chemical Name or Material U0126
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