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TPEN, Tocris Bioscience™

Product Code. 18085592
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Quantity:
100 mg
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Description

Cell-permeable Zn2+ chelator; also inhibits RNA binding protein Lin28

Heavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK1 cells; acts as an intracellular chelator of proteomic Zn2+. Activity decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells. Also inhibits RNA binding protein Lin28 (IC50 = 2.5 μM). Cell permeable.

Specifications

CAS 16858-02-9
Molecular Formula C26H28N6
MDL Number MFCD00036918
Quantity 100 mg
Synonym tpen, n,n,n',n'-tetrakis 2-pyridylmethyl ethylenediamine, n1,n1,n2,n2-tetrakis pyridin-2-ylmethyl ethane-1,2-diamine, unii-r9ptu1u29i, n,n,n',n'-tetrakis 2-pyridylmethyl ethane-1,2-diamine, r9ptu1u29i, n,n,n',n'-tetrakis 2-pyridyl-methyl ethylenediamine, 1,2-ethanediamine, n,n,n',n'-tetrakis 2-pyridinylmethyl-, oc-6-11, 1,2-ethanediamine,n,n,n',n'-tetrakis 2-pyridinylmethyl, 1,2-ethanediamine, n,n,n',n'-tetrakis 2-pyridinylmethyl
InChI Key CVRXLMUYFMERMJ-UHFFFAOYSA-N
SMILES C(CN(CC1=CC=CC=N1)CC1=CC=CC=N1)N(CC1=CC=CC=N1)CC1=CC=CC=N1
IUPAC Name (2-{bis[(pyridin-2-yl)methyl]amino}ethyl)bis[(pyridin-2-yl)methyl]amine
Molecular Weight (g/mol) 424.55
PubChem CID 5519
Formula Weight 424.54
Percent Purity >98%
Chemical Name or Material TPEN
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