missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. Benzenesulfonamides
  8. TMI 1, >98%, Tocris Bioscience™

TMI 1, >98%, Tocris Bioscience™

Product Code. 30000996
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Adam 17 (TACE) and MMP inhibitor (IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF-α production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro. Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable.

Chemical Identifiers

CAS 287403-39-8
Molecular Formula C17H22N2O5S2
Molecular Weight (g/mol) 398.492
InChI Key CVZIHNYAZLXRRS-HNNXBMFYSA-N
Synonym tmi-1, 3s-4-4-but-2-ynyloxy phenyl sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide, ih6, 3s-4-4-but-2-yn-1-yloxy benzenesulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide, 1zxc, tmi 1, tmi hplc, 3s-4-4-but-2-ynoxyphenyl sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide, 3s-4-4-2-butyn-1-yloxy phenyl sulfonyl-n-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide, 3s-4-4-but-2-yn-1-yloxy benzene sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
PubChem CID 5288615
IUPAC Name (3S)-4-(4-but-2-ynoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
SMILES CC#CCOC1=CC=C(C=C1)S(=O)(=O)N2CCSC(C2C(=O)NO)(C)C

Specifications

Linear Formula C17H22N2O5S2
Quantity 50 mg
Solubility Information Soluble to 100mM in DMSO and to 20mM in ethanol
Formula Weight 398.49
Chemical Name or Material (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide
Grade >98%
missing translation for 'provideContentCorrection'

missing translation for 'productTitle'

missing translation for 'byClickingSubmit' missing translation for 'privacyPolicy'.