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  6. TC ASK 10, Tocris Bioscience™

TC ASK 10, Tocris Bioscience™

Product Code. 30001618
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective ASK1 inhibitor; orally bioavailable

Potent ASK1 inhibitor (IC50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 μM), MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf (IC50 values are > 10 μM). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.

Chemical Identifiers

CAS 1005775-56-3
Molecular Formula C21H23Cl2N5O
Molecular Weight (g/mol) 432.349
InChI Key IKKLFEDUYFZNBO-UHFFFAOYSA-N
Synonym ask1 inhibitor 10, tc ask 10, 4-tert-butyl-n-6-1h-imidazol-1-yl imidazo 1,2-a pyridin-2-yl benzamide dihydrochloride, 4-1,1-dimethylethyl-n-6-1h-imidazol-1-yl imidazo 1,2-a pyridin-2-yl benzamide dihydrochloride
PubChem CID 68661090
IUPAC Name 4-tert-butyl-N-(6-imidazol-1-ylimidazo[1,2-a]pyridin-2-yl)benzamide;dihydrochloride
SMILES CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CN3C=C(C=CC3=N2)N4C=CN=C4.Cl.Cl

Specifications

Quantity 10 mg
Formula Weight 432.35
Percent Purity >98%
Chemical Name or Material TC ASK 10
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