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  8. SL 327, Tocris Bioscience™

SL 327, Tocris Bioscience™

Product Code. 18095052
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Quantity:
1 mg
10 mg
50 mg
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Description

Selective inhibitor of MEK1 and MEK2; brain penetrant

Selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Chemical Identifiers

CAS 305350-87-2
Molecular Formula C16H12F3N3S
Molecular Weight (g/mol) 335.348
InChI Key JLOXTZFYJNCPIS-FYWRMAATSA-N
Synonym mek1/2 inhibitor, z-3-amino-3-4-aminophenylthio-2-2-trifluoromethyl phenyl acrylonitrile, 2z-3-amino-3-4-aminophenyl sulfanyl-2-2-trifluoromethyl phenyl prop-2-enenitrile, z-& e-alpha-amino-4-aminophenyl thio methylene-2-trifluoromethyl benzeneacetonitrile, d04wpa, alpha-amino-4-aminophenylthio methylene-2-trifluoromethyl phenylacetonitrile, sl hplc , mixture of e & z isomers, solid, 3-amino-3-4-aminophenyl sulfanyl-2-2-trifluoromethyl phenyl acrylonitrile, 3-amino-3-4-aminophenyl thio-2-2-trifluoromethyl phenyl-2-propenenitrile, alpha-amino 4-aminophenyl thio methylene-2-trifluoromethyl benzeneacetonitrile
PubChem CID 9549284
IUPAC Name (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
SMILES C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

Specifications

Quantity 1 mg
Formula Weight 335.35
Percent Purity >99%
Chemical Name or Material SL 327
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