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  8. SKF 89976A hydrochloride, Tocris Bioscience™

SKF 89976A hydrochloride, Tocris Bioscience™

Product Code. 18064812
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent GAT-1 inhibitor; brain penetrant

A potent GABA uptake inhibitor, selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo.

Chemical Identifiers

CAS 85375-15-1
Molecular Formula C22H26ClNO2
Molecular Weight (g/mol) 371.905
InChI Key SNGGBKYQZVAQKA-UHFFFAOYSA-N
Synonym skf 89976a hydrochloride, 1-4,4-diphenylbut-3-en-1-yl piperidine-3-carboxylic acid hydrochloride, 1-4,4-diphenyl-3-butenyl-3-piperidinecarboxylic acid hydrochloride, skf89976a hydrochloride, 1-4,4-diphenylbut-3-enyl piperidine-3-carboxylic acid hydrochloride, 1-4,4-diphenyl-3-buten-1-yl-3-piperidinecarboxylic acid hydrochloride, skf 89976a hcl, SK&F 89976-a, hydrochloride, skf-89976a hplc , solid
PubChem CID 6917797
IUPAC Name 1-(4,4-diphenylbut-3-enyl)piperidine-3-carboxylic acid;hydrochloride
SMILES C1CC(CN(C1)CCC=C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O.Cl

Specifications

Quantity 10 mg
Formula Weight 371.91
Percent Purity >99%
Chemical Name or Material SKF 89976A hydrochloride
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