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  8. SI-2 hydrochloride, >98%, Tocris Bioscience™

SI-2 hydrochloride, >98%, Tocris Bioscience™

Product Code. 30000956
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Quantity:
10 mg
50 mg
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Description

Steroid receptor coactivator 3 (SRC-3) inhibitor

Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Chemical Identifiers

CAS 287403-39-8
Molecular Formula C17H22N2O5S2
Molecular Weight (g/mol) 398.492
InChI Key CVZIHNYAZLXRRS-HNNXBMFYSA-N
Synonym tmi-1, 3s-4-4-but-2-ynyloxy phenyl sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide, ih6, 3s-4-4-but-2-yn-1-yloxy benzenesulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide, 1zxc, tmi 1, tmi hplc, 3s-4-4-but-2-ynoxyphenyl sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide, 3s-4-4-2-butyn-1-yloxy phenyl sulfonyl-n-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide, 3s-4-4-but-2-yn-1-yloxy benzene sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
PubChem CID 5288615
IUPAC Name (3S)-4-(4-but-2-ynoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
SMILES CC#CCOC1=CC=C(C=C1)S(=O)(=O)N2CCSC(C2C(=O)NO)(C)C

Specifications

Linear Formula C15H15N5.HCl
Quantity 10 mg
Solubility Information Soluble to 50mM in water and to 20mM in DMSO
Formula Weight 301.78
Chemical Name or Material (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide
Grade >98%
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