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SANT-1, Tocris Bioscience™

Product Code. 18085972
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Has been used in protocols to generate pancreatic β cells from hPSCs.

For more information about how SANT-1 may be used, see our protocol:

Generation of β cells from hPSCs
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 304909-07-7
Molecular Formula C23H27N5
Molecular Weight (g/mol) 373.50
MDL Number MFCD01827306
InChI Key FOORCIAZMIWALX-UHFFFAOYSA-N
Synonym sant-1, shh signaling antagonist v, 4-benzyl-piperazin-1-yl-3,5-dimethyl-1-phenyl-1h-pyrazol-4-ylmethylene-amine, e-4-benzyl-n-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methylene piperazin-1-amine, n-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methylene-4-phenylmethyl-1-piperazinamine, n-4-benzylpiperazin-1-yl-1-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methanimine, e-n-4-benzylpiperazin-1-yl-1-3,5-dimethyl-1-phenylpyrazol-4-yl methanimine, 4-benzyl-n-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methylene piperazin-1-amine, 4-benzyl-n-e-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methylidene piperazin-1-amine
PubChem CID 6878030
IUPAC Name N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
SMILES CC1=NN(C(C)=C1C=NN1CCN(CC2=CC=CC=C2)CC1)C1=CC=CC=C1

Specifications

Quantity 50 mg
Formula Weight 373.5
Percent Purity >99%
Chemical Name or Material SANT-1
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