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  7. (S)-Crizotinib, >98%, Tocris Bioscience™

(S)-Crizotinib, >98%, Tocris Bioscience™

Product Code. 30000947
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

MTH1 inhibitor

Potent MTH1 inhibitor (IC50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ∽50% in a colon cancer carcinoma xenograft model.

Chemical Identifiers

CAS 1374356-45-2
Molecular Formula C21H22Cl2FN5O
Molecular Weight (g/mol) 450.339
InChI Key KTEIFNKAUNYNJU-LBPRGKRZSA-N
Synonym s-crizotinib, ent-crizotinib, s-3-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-amine, 3-1s-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-ylpyrazol-4-yl pyridin-2-amine, tube712, d03ozd, s-crizotinib hplc, s-3-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-am ine, 3-1s-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-4-piperidinyl-1h-pyrazol-4-yl-2-pyridinamine, 3-1s-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-amine
PubChem CID 56671814
ChEBI CHEBI:77555
IUPAC Name 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
SMILES CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Specifications

Linear Formula C21H22Cl2FN5O
Quantity 10 mg
Solubility Information Soluble to 50mM in DMSO and to 20mM in 1eq. HCl with gentle warming
Formula Weight 450.34
Chemical Name or Material 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
Grade >98%
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