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  7. PHA 767491 hydrochloride, Tocris Bioscience™

PHA 767491 hydrochloride, Tocris Bioscience™

Product Code. 18085002
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Quantity:
10 mg
50 mg
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Description

MK2 inhibitor; also cdk inhibitor; potently inhibits cdk9

ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.034 - 0.75, 0.24 - 1.2, 0.25 - 1.1 and 0.46 - 1 μM for cdk9, cdk2, cdk1 and cdk5, respectively). Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2; IC50 = 171 nM). Prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo.

Chemical Identifiers

CAS 942425-68-5
Molecular Formula C12H12ClN3O
Molecular Weight (g/mol) 249.698
InChI Key IMVNFURYBZMFDZ-UHFFFAOYSA-N
Synonym pha 767491 hydrochloride, pha-767491 hydrochloride, 1,5,6,7-tetrahydro-2-4-pyridinyl-4h-pyrrolo 3,2-c pyridin-4-one hydrochloride, 2-pyridin-4-yl-1h,5h,6h,7h-pyrrolo 3,2-c pyridin-4-one hydrochloride, cay-10572 hydrochloride, pha-00767491 hydrochloride, pha 767491 hydrochloride hplc, 1,5,6,7-tetrahydro-2-4-pyridinyl-??4h-pyrrolo 3,2-c pyridin-4-one hydrochloride, 2-pyridin-4-yl-1,5,6,7-tetrahydro-4h-pyrrolo 3,2-c pyridin-4-one hydrochloride
PubChem CID 11715766
IUPAC Name 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one;hydrochloride
SMILES C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3.Cl

Specifications

Quantity 50 mg
Formula Weight 249.7
Percent Purity >99%
Chemical Name or Material PHA 767491 hydrochloride
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