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PF 573228, Tocris Bioscience™

Product Code. 18024982
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Quantity:
10 mg
50 mg
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Description

Potent and selective FAK inhibitor

Potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. Blocks serum and fibronectin-directed migration and decreases focal adhesion turnover in vitro.

Chemical Identifiers

CAS 869288-64-2
Molecular Formula C22H20F3N5O3S
Molecular Weight (g/mol) 491.49
MDL Number MFCD11519967
InChI Key HESLKTSGTIBHJU-UHFFFAOYSA-N
Synonym 3,4-dihydro-6-4-3-methylsulfonyl phenyl methyl amino-5-trifluoromethyl-2-pyrimidinyl amino-2 1h-quinolinone, 6-4-3-methylsulfonyl benzylamino-5-trifluoromethyl pyrimidin-2-ylamino-3,4-dihydroquinolin-2 1h-one, 6-4-3-methanesulfonyl-benzylamino-5-trifluoromethyl-pyrimidin-2-ylamino-3,4-dihydro-1h-quinolin-2-one, 3,4-dihydro-6-4-3-methylsulfonyl phenyl methyl amino-5-trifluoromethyl-pyrimidin-2-yl amino-2 1h-quinolinone, 6-4-3-methanesulfonyl benzyl amino-5-trifluoromethylpyrimidin-2-yl amino-3,4-dihydro-1h-quinolin-2-one, 6-4-3-methylsulfonyl benzyl amino-5-trifluoromethyl pyrimidin-2-yl amino-3,4-dihydroquinolin-2 1h-one, 6-4-3-methanesulfonylphenyl methyl amino-5-trifluoromethyl pyrimidin-2-yl amino-3,4-dihydro-1h-quinolin-2-one, d02qaz, pf hplc
PubChem CID 11612883
IUPAC Name 6-[(4-{[(3-methanesulfonylphenyl)methyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl)amino]-1,2,3,4-tetrahydroquinolin-2-one
SMILES CS(=O)(=O)C1=CC=CC(CNC2=NC(NC3=CC4=C(NC(=O)CC4)C=C3)=NC=C2C(F)(F)F)=C1

Specifications

Quantity 10 mg
Formula Weight 491.49
Percent Purity >98%
Chemical Name or Material PF 573228
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