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  8. NU 6140, Tocris Bioscience™

NU 6140, Tocris Bioscience™

Product Code. 18035082
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Quantity:
10 mg
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Description

Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

Cyclin-dependent kinase 2 (cdk2) inhibitor (IC50 values are 0.42 - 1.1 μM). Displays some selectivity for cdk2 (IC50 value = 0.94 μM for cdk4 and >2.3 μM for other cdks). Induces cell-cycle arrest at the G2-M phase. Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin. Also potently inhibits aurora kinases (IC50 values are 0.035 and 0.067 μM for aurora kinase B and A, respectively).

Chemical Identifiers

CAS 444723-13-1
Molecular Formula C23H30N6O2
Molecular Weight (g/mol) 422.533
InChI Key XHEQSRJCJTWWAH-UHFFFAOYSA-N
Synonym cdk2 inhibitor iv, nu6140, 4-6-cyclohexylmethoxy-9h-purin-2-ylamino-n,n-diethylbenzamide, cdk2 inhibitor iv, d04wfn, nu hplc, 4-6-cyclohexylmethoxy-9hpurin-2-ylamino-n,n-diethyl-benzamide, 4-6-cyclohexylmethoxy-1h-purin-2-yl amino-n,n-diethylbenzamide, 4-6-cyclohexylmethoxy-7h-purin-2-yl amino-n,n-diethylbenzamide, 4-6-cyclohexylmethoxy-9h-purin-2-yl amino-n,n-diethylbenzamide
PubChem CID 10202471
IUPAC Name 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide
SMILES CCN(CC)C(=O)C1=CC=C(C=C1)NC2=NC3=C(C(=N2)OCC4CCCCC4)NC=N3

Specifications

Quantity 10 mg
Formula Weight 422.52
Percent Purity >99%
Chemical Name or Material NU 6140
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