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  7. 18075462

NSC 663284, Tocris Bioscience™

Product Code. 18075462
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Quantity:
10 mg
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Description

Potent, selective Cdc25 phosphatase inhibitor

Potent, selective inhibitor of Cdc25 dual specificity phosphatases (Ki values are 29, 95 and 89 nM for human Cdc25A, Cdc25B2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC50 = 0.2 - 35 μM).

Specifications

CAS 383907-43-5
Molecular Formula C15H16ClN3O3
MDL Number MFCD08276924
Quantity 10 mg
Synonym cdc25 phosphatase inhibitor ii, nsc 663284, 6-chloro-7-2-morpholin-4-yl-ethylamino quinoline-5,8-dione, 6-chloro-7-2-morpholin-4-yl ethyl amino quinoline-5,8-dione, d0xu7m, nsc hplc , solid, 5,6-chloro-7-2-4-morpholinyl ethyl amino, cdc25 phosphatase inhibitor ii, nsc 663284_x000d_, 6-chloro-7-2-morpholinoethyl amino quinoline-5,8-dione, 7-n-aminoethyl-4-morpholino-6-chloro-5,8-quinolinedione, 6-chloro-7-2-morpholin-4-ylethylamino quinoline-5,8-dione
InChI Key BMKPVDQDJQWBPD-UHFFFAOYSA-N
SMILES ClC1=C(NCCN2CCOCC2)C(=O)C2=C(C=CC=N2)C1=O
IUPAC Name 6-chloro-7-{[2-(morpholin-4-yl)ethyl]amino}-5,8-dihydroquinoline-5,8-dione
Molecular Weight (g/mol) 321.76
PubChem CID 379077
Formula Weight 321.76
Percent Purity >99%
Chemical Name or Material NSC 663284
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