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Tocris Bioscience™ NR 162

Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor

Brand:  Tocris Bioscience™ 7572/10

Product Code. 18737786

  • 279.00€ / 10mg

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Description

Description

NR 162 is a potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor (IC50 = 80 nM); it exhibits no significant activity against related kinases MERTK, AXL and ABL1 and ~ 47-fold selectivity over TYRO3 (IC50 = 3.8 μM). NR 162 targets the unique pocket created by CASK GFG motif; it is a type-I inhibitor which stabilizes the active state of CASK without affecting the scaffolding function. NR 162 induces cell death in actively differentiating cells of the P19 neuronal differentiation model. NR 162 shows no toxicity in differentiated cells, or in cancer cells.
Specifications

Specifications

4-(Cyclopentylamino)-2-((2,5-dibromo-4-methylbenzyl)amino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide
10 mg
C24H30Br2N6O3
2755241-73-5
CaM Kinase Inhibitors
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