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Thermo Scientific Chemicals Metronidazole, 99%
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Metronidazole is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities and acts against protozoa, anaerobic gram-positive, and anaerobic gram-negative bacteria
• Metronidazole is considered a prodrug that produces nitroso-containing intermediates in the cell that can covalently bind DNA, disrupting helical structure, inducing DNA strand breaks, and inhibiting bacterial nucleic acid synthesis, that results in bacterial cell death
Applications
• Metronidazole shows anti-parasitic and anti-amoebic activities.
• It has been used to prevent the growth of gram-negative anaerobes belonging to the Bacteroides and Fusobacterium, and gram-positive anaerobes such as Peptostreptococcus and Clostridia. This compound affects a high percentage of gram-negative bacteria and has higher tissue penetration that gives it an advantage compared to other compounds.
• This compound was used initially to suppress protozoans such as Entamoeba histolytica, Giardia lamblia, and Trichomonas vaginalis.
• It has been commonly applied for the eradication of Helicobacter pylori.
• It also has a radio-sensitizing effect on hypoxic tumor cells and can have a mutagenic activity in in vivo animal models.
Specifications
Specifications
| CAS Min % | 98.5 |
| CAS Max % | 100.0 |
| Melting Point | 159°C to 163°C |
| Color | White to Yellow |
| Infrared Spectrum | Authentic |
| Assay Percent Range | 99% |
| Packaging | Glass bottle |
| Quantity | 5 g |
| Merck Index | 15, 6236 |
| Solubility Information | Solubility in water: 1g/100mL (20°C). Other solubilities: soluble in diluted acids,0.5g/100mL ethanol- <0.05g/100mL ether (20°C),<0.05g/100mL chloroform (20°C),sparingly soluble in dmf |
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Safety and Handling
- Metronidazole
- Warning
- Carcinogenicity Category 1B
- Germ cell mutagenicity Category 2
- H341-Suspected of causing genetic defects.
- H350-May cause cancer.
- H412-Harmful to aquatic life with long lasting effects.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P201-Obtain special instructions before use.
- P308+P313-IF exposed or concerned: Get medical advice/attention.
RUO – Research Use Only
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