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  6. Melphalan, 94%, Thermo Scientific Chemicals

Melphalan, 94%, Thermo Scientific Chemicals

Product Code. 15572343
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Quantity:
1 g
5 g

Description

Melphalan, CAS # 148-82-3, belongs to the class of nitrogen mustards with anti-neoplastic activity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity with the capacity to alkylate nucleic acids
Melphalan alkylates DNA at the N-7 position of guanine and induces DNA interstrand cross-linkages, resulting in the inhibition of DNA/RNA synthesis, inducing cytotoxicity against both dividing and non-dividing tumor cells
Applications
Melphalan has been used in in vitro experiments to treat multiple myeloma in cell lines and breast cancer cell lines
In in vivo experiments, using rats, it shows a potent therapeutic effect in cases of sarcomatous pulmonary metastases
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 148-82-3
Molecular Formula C13H18Cl2N2O2
Molecular Weight (g/mol) 305.2
InChI Key SGDBTWWWUNNDEQ-LBPRGKRZSA-N
Synonym melphalan, alkeran, melfalan, phenylalanine mustard, l-sarcolysine, l-pam, l-sarcolysin, l-phenylalanine mustard, levofalan, p-l-sarcolysin
PubChem CID 460612
ChEBI CHEBI:28876
IUPAC Name (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
SMILES C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl

Specifications

Melting Point 180.0°C
Infrared Spectrum Authentic
Assay Percent Range 93% min. (HPLC)
Linear Formula (ClCH2CH2)2NC6H4CH2CH(NH2)COOH
Quantity 5 g
Formula Weight 305.2
Percent Purity 94%
Chemical Name or Material Melphalan

Safety and Handling

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Product Identifier
  • Melphalan
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 1
  • Acute toxicity Category 2
  • Carcinogenicity Category 1B
  • Serious eye damage/eye irritation Category 2
  • Reproductive toxicity Category 2
  • Skin corrosion/irritation Category 2
 Hazard Statement
  • H330-Fatal if inhaled.
  • H350-May cause cancer.
  • H310-Fatal in contact with skin.
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H361-Suspected of damaging fertility or the unborn child.
  • H300-Fatal if swallowed.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P362-Take off contaminated clothing.

RUO – Research Use Only

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