missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organosulfur Compounds
  6. Thioureas
  7. Mdivi 1, Tocris Bioscience™

Mdivi 1, Tocris Bioscience™

Product Code. 18084462
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.

Chemical Identifiers

CAS 338967-87-6
Molecular Formula C15H10Cl2N2O2S
Molecular Weight (g/mol) 353.217
InChI Key NZJKEVWTYMOYOR-UHFFFAOYSA-N
Synonym mdivi-1, mdivi 1, 3-2,4-dichloro-5-methoxyphenyl-2-sulfanyl-4 3h-quinazolinone, 3-2,4-dichloro-5-methoxyphenyl-2-sulfanylidene-1h-quinazolin-4-one, 3-2,4-dichloro-5-methoxyphenyl-2,3-dihydro-2-thioxo-4 1h-quinazolinone, mdivi hplc , powder, 3-2,4-dichloro-5-methoxyphenyl-2-mercaptoquinazolin-4 3h-one, 3-2,4-dichloro-5-methoxyphenyl-2-sulfanylquinazolin-4-one, 3-2,4-dichloro-5-methoxyphenyl-2-thioxo-2,3-dihydro-4 1h-quinazolinone
PubChem CID 3825829
IUPAC Name 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one
SMILES COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl

Specifications

Quantity 10 mg
Formula Weight 353.22
Percent Purity >98%
Chemical Name or Material Dynamin Inhibitors
missing translation for 'provideContentCorrection'

missing translation for 'productTitle'

missing translation for 'byClickingSubmit' missing translation for 'privacyPolicy'.