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MGMT (O-methylguanine-DNA methyltransferase) Ab-1 Mouse Monoclonal Antibody, Epredia™
Epredia™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.
Brand: Epredia MS-470-P1
401.28 EUR valid until 2024-12-31
Use promo code "21628" to get your promotional price.
This item is not returnable.
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Description
Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.Host Species: Mouse
Clone: MT 3.1
Isotype: IgG1
Species Reactivity: Human. Also reacts weakly with Mouse, Rat and Hamster. Others not known.
Epitope: aa 8-221
Immunogen: Purified recombinant human MGMT protein
Molecular Weight: 25kDa
Positive Control: Raji cells, Colon CA
Cellular Localization: Nuclear and cytoplasmic
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Specifications
| MGMT (O-methylguanine-DNA methyltransferase) Ab-1 | |
| Monoclonal | |
| 200μg/mL | |
| Mouse | |
| 500 μL | |
| Enzyme | |
| Hamster, Human, Mouse, Rat | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| MT 3.1 | |
| Unconjugated | |
| Purified recombinant human MGMT protein | |
| RUO | |
| Primary | |
| Concentrated |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- APD Primary Antibody Products, Antibody Diluent
Signal Word
- Danger
Hazard Category
- Respiratory sensitiser Category 1
- Skin sensitiser Category 1
Hazard Statement
- H317-May cause an allergic skin reaction.
- H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statement
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P284-¢In case of inadequate ventilation! wear respiratory protection.
- P272-Contaminated work clothing should not be allowed out of the workplace.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P302+P352-IF ON SKIN: Wash with plenty of water/and soap.
- P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
- P363-Wash contaminated clothing before reuse.
Supplemental information
- MIXTURE LIST-Contains : Albumins, blood serum, Sodium azide, Antibody (Animal)
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