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CD137 (4-1BB) Ab-1 Mouse Monoclonal Antibody, Epredia™
Epredia™ CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.
Brand: Epredia MS-621-P1
This item is not returnable.
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Description
4-1BB (also known as CD137) is an inducible receptor-like protein expressed on the cell surface of activated splenic T cells and thymocytes. It exists as both a monomer and a dimer on the surface of activated T cells. 4-1BB is structurally related to the members of NGFR/TNFR superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains. Other members of this family include low affinity NGFR, two receptors for TNF (TNFR-I & TNFR-II), CD30, CD40, OX40, Fas, and CD27. These molecules are involved in cell growth, survival, and death processes. The cytoplasmic domain of 4-1BB include two runs of acidic amino acids, a potential p56lck binding site, five consecutive glycines at the C-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine.Host Species: Mouse
Clone: BBK-2
Isotype: IgG1/κ
Species Reactivity: Human. Others not known.
Epitope: Ectodomain
Immunogen: Ectodomain of human 4-1BB recombinant protein
Molecular Weight: 30kDa
Positive Control: Spleen, thymus or tonsil
Cellular Localization: Membrane
Recommended for:
- Immunofluorescence
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Specifications
| CD137 Ab-1 | |
| Monoclonal | |
| 200μg/mL | |
| Mouse | |
| 500 μL | |
| Apoptosis | |
| Human | |
| IgG1 κ |
| Flow Cytometry, Immunofluorescence | |
| BBK-2 | |
| Unconjugated | |
| Ectodomain of human 4-1BB recombinant protein | |
| RUO | |
| Primary | |
| Concentrated |
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