missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Indoles and derivatives
  7. Ko 143, Tocris Bioscience™

Ko 143, Tocris Bioscience™

Product Code. 18004752
Click to view available options
Quantity:
1 mg
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective BCRP inhibitor

Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. Inhibits ABCB1 and ABCC1 at higher concentrations. Rapidly metabolized in rat plasma.

Chemical Identifiers

CAS 461054-93-3
Molecular Formula C26H35N3O5
Molecular Weight (g/mol) 469.58
MDL Number MFCD11042273,MFCD19053160
InChI Key NXNRAECHCJZNRF-UHFFFAOYNA-N
Synonym tert-butyl 3-3s,6s,12as-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino 1',2':1,6 pyrido 3,4-b indol-3-yl propanoate, ko143 hydrate, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester hydrate, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl 1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1,2:1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 1,1-dimethylethyl 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoate, 3-3s,6s-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino 1,2:1,6 pyrido 3,4-b indol-3-yl-propionic acid tert-butyl ester, 3-3s,6s,12as-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino 1,2:1,6 pyrido 3,4-b indol-3-yl-propionic acid tert-butyl ester
PubChem CID 10322450
IUPAC Name tert-butyl 3-[14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
SMILES COC1=CC=C2C(NC3=C2CC2N(C3CC(C)C)C(=O)C(CCC(=O)OC(C)(C)C)NC2=O)=C1

Specifications

Quantity 1 mg
Formula Weight 469.57
Percent Purity >99%
Chemical Name or Material Ko 143
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.