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Invitrogen™ IKK epsilon Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA528264
This item is not returnable.
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Description
Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (84%), Rat (85%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
IKBKE is an activator of nuclear factor-kappa-B. Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death. NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma. A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i. IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1. IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.
Specifications
| IKK epsilon | |
| Polyclonal | |
| Unconjugated | |
| IKBKE | |
| AW558201; I-kappa-B kinase epsilon; Ikbke; IKKE; IKK-E; IKKepsilon; IKK-epsilon; IKKI; IKK-i; IKK-related kinase epsilon; inducible I kappa-B kinase; inducible IkappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; RP11-534L20.1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 56489, 9641 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q14164, Q9R0T8 | |
| IKBKE | |
| Recombinant protein encompassing a sequence within the center region of human IKK epsilon. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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