missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organic acids and derivatives
  6. Carboxylic acids and derivatives
  7. Carboxylic acid imides
  8. iCRT 14, Tocris Bioscience™

iCRT 14, Tocris Bioscience™

Product Code. 18054972
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibits β-catenin-responsive transcription (CRT)

Potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.

Chemical Identifiers

CAS 677331-12-3
Molecular Formula C21H17N3O2S
Molecular Weight (g/mol) 375.446
InChI Key NCSHZXNGQYSKLR-UNOMPAQXSA-N
Synonym icrt 14, icrt-14, icrt14, 5-2,5-dimethyl-1-3-pyridinyl-1h-pyrrol-3-yl methylene-3-phenyl-2,4-thiazolidinedione, 5z-5-2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl methylidene-3-phenyl-1,3-thiazolidine-2,4-dione, icrt hplc, 5-2,5-dimethyl-1-3-pyridinyl-1h-pyrrol-3-yl methylene-3-phenyl-2,4-thiazolidinedion, 5z-5-2,5-dimethyl-1-pyridin-3-yl-1h-pyrrol-3-yl methylidene-3-phenyl-1,3-thiazolidine-2,4-dione, 5z-5-2,5-dimethyl-1-pyridin-3-yl pyrrol-3-yl methylidene-3-phenyl-1,3-thiazolidine-2,4-dione
PubChem CID 5967294
IUPAC Name (5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
SMILES CC1=CC(=C(N1C2=CN=CC=C2)C)C=C3C(=O)N(C(=O)S3)C4=CC=CC=C4

Specifications

Quantity 50 mg
Formula Weight 375.44
Percent Purity >99%
Chemical Name or Material iCRT 14
missing translation for 'provideContentCorrection'

missing translation for 'productTitle'

missing translation for 'byClickingSubmit' missing translation for 'privacyPolicy'.