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iCRT 14, Tocris Bioscience™

Product Code. 18025712
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibits β-catenin-responsive transcription (CRT)

Potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.

Chemical Identifiers

CAS 677331-12-3
Molecular Formula C21H17N3O2S
Molecular Weight (g/mol) 375.446
InChI Key NCSHZXNGQYSKLR-UNOMPAQXSA-N
Synonym icrt 14, icrt-14, icrt14, 5-2,5-dimethyl-1-3-pyridinyl-1h-pyrrol-3-yl methylene-3-phenyl-2,4-thiazolidinedione, 5z-5-2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl methylidene-3-phenyl-1,3-thiazolidine-2,4-dione, icrt hplc, 5-2,5-dimethyl-1-3-pyridinyl-1h-pyrrol-3-yl methylene-3-phenyl-2,4-thiazolidinedion, 5z-5-2,5-dimethyl-1-pyridin-3-yl-1h-pyrrol-3-yl methylidene-3-phenyl-1,3-thiazolidine-2,4-dione, 5z-5-2,5-dimethyl-1-pyridin-3-yl pyrrol-3-yl methylidene-3-phenyl-1,3-thiazolidine-2,4-dione
PubChem CID 5967294
IUPAC Name (5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
SMILES CC1=CC(=C(N1C2=CN=CC=C2)C)C=C3C(=O)N(C(=O)S3)C4=CC=CC=C4

Specifications

Quantity 10 mg
Formula Weight 375.44
Percent Purity >99%
Chemical Name or Material iCRT 14
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