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Gibco™ Human Oncostatin M (196 aa) Recombinant Protein, PeproTech®

Product Code. 17881693
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500 μg
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10µg
1mg
250µg
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500µg
50µg
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Product Code. 17881693

Brand: Gibco™ 30010H500UG

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Description

Recombinant Protein

PeproTech's Recombinant Human Oncostatin M (196 a.a.) is a HEK293 cell-derived, 196 amino-acid length glycoprotein that has a calculated theoretical molecular weight of 22.2 kDa, but migrates at an apparent molecular weight of 32-34 kDa by SDS-PAGE analysis under reducing conditions due to glycosylation. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.
TRUSTED_SUSTAINABILITY

Spécification

Accession Number P13725
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 5008
Molecular Weight (g/mol) 22.2 kDa
Name Human Oncostatin M (196 aa)
Quantity 500 μg
Source HEK293 cells
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias MGC20461; OncoM; oncostatin M; oncostatin-M; OSM
Common Name Oncostatin M
Gene Symbol OSM
Biological Activity Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg
Conjugate Unconjugated
Recombinant Recombinant
Sequence AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRR
Content And Storage -20°C
Expression System HEK293 cells
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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