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Gibco™ Human MATE1 (G) SLC Transporter Cells
HEK293 cells that transiently overexpress the OATP2B1 solute carrier (SLC) transport protein
Brand: Gibco™ GM1114G
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Description
- TRANSiPORT Human MATE1 (G) SLC Transporter Cells are HEK293 cells that transiently overexpress the OATP2B1 solute carrier (SLC) transport protein. Solute carriers are a super-family of membrane transporters that can affect pharmacokinetics and drug exposure by governing the transport of solutes in and out of cells. TheMATE1 SLC transporter protein is found in hepatocytes.
- Assess potential for transporter-mediated drug metabolism
- Easy-to-use format
- Obtain high-quality results with a large signal-to-noise ratio
- Cell-based assays can be performed using radioisotope-labeled compounds, fluorescence-labeled compounds, or non-labeled compounds. The amount of substrate transported into the cells can be measured directly using a liquid scintillation counter, fluorescence plate reader, or LC-MS/MS, thereby allowing direct evaluation of SLC transporter activity.
- Mock (G) SLC Transporter Cells (Cat. No. GM1101G) that do not overexpress the SLC transporter are available for use as a negative experimental control. Some compounds may demonstrate high background levels of transport due to the presence of endogenous transporters or non-specific binding.
- The convenient product format enables data generation in two days from thawing of the cells to final results.
Specifications
| Store in liquid nitrogen vapor phase. | |
| Mammalian Cell Culture | |
| SLC Transporter Cell |
| 293 (HEK) | |
| Human | |
| 8-10 x 106 cells |
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