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  8. GW 843682X, Tocris Bioscience™

GW 843682X, Tocris Bioscience™

Product Code. 18094172
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Description

Selective inhibitor of PLK1 and PLK3

Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ∽30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.

Chemical Identifiers

CAS 660868-91-7
Molecular Formula C22H18F3N3O4S
Molecular Weight (g/mol) 477.458
InChI Key JSKUWFIZUALZLX-UHFFFAOYSA-N
Synonym 5-5,6-dimethoxy-1h-benzimidazol-1-yl-3-2-trifluoromethyl-benzyl oxy thiophene-2-carboxamide, 5-5,6-dimethoxy-1h-benzimidazol-1-yl-3-2-trifluoromethyl benzyl oxy thiophene-2-carboxamide, 5-5,6-dimethoxybenzimidazol-1-yl-3-2-trifluoromethyl phenyl methoxy thiophene-2-carboxamide, kinome_3462, thiophene deriv., 20, bmcl191018 compound 2, gw843682x hplc , solid, 3-2-trifluoromethyl benzyloxy-5-5,6-dimethoxy-1h-benzo d imidazol-1-yl thiophene-2-carboxamide, 5-5,6-dimethoxy-1,3-benzodiazol-1-yl-3-2-trifluoromethyl phenyl methoxy thiophene-2-carboxamide, 5-5,6-dimethoxy-1-benzimidazolyl-3-2-trifluoromethyl phenyl methoxy-2-thiophenecarboxamide
PubChem CID 9826308
IUPAC Name 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide
SMILES COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC

Specifications

Quantity 1 mg
Formula Weight 477.46
Percent Purity >98%
Chemical Name or Material GW 843682X
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