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  7. Genistein, Tocris Bioscience™

Genistein, Tocris Bioscience™

Catalog Number 18712804
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
446-72-0
C15H10O5
270.24
MFCD00016952
TZBJGXHYKVUXJN-UHFFFAOYSA-N
genistein, prunetol, genisteol, 4',5,7-trihydroxyisoflavone, genisterin, sophoricol, 5,7,4'-trihydroxyisoflavone, bonistein, 5,7-dihydroxy-3-4-hydroxyphenyl-4h-chromen-4-one, genestein
5280961
CHEBI:28088
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
OC1=CC=C(C=C1)C1=COC2=CC(O)=CC(O)=C2C1=O
This item is not returnable. View return policy
446-72-0
C15H10O5
270.24
MFCD00016952
TZBJGXHYKVUXJN-UHFFFAOYSA-N
genistein, prunetol, genisteol, 4',5,7-trihydroxyisoflavone, genisterin, sophoricol, 5,7,4'-trihydroxyisoflavone, bonistein, 5,7-dihydroxy-3-4-hydroxyphenyl-4h-chromen-4-one, genestein
5280961
CHEBI:28088
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
OC1=CC=C(C=C1)C1=COC2=CC(O)=CC(O)=C2C1=O

Description

EGFR kinase inhibitor. Also estrogen and PPARγ ligand

Genistein is a phytoestrogen with a wide range of biological actions. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase, binds to PPARγ and estrogen receptors and acts as an agonist at GPER. Genistein inhibits aggregation and fibrilization of Aβ42 and amylin37 (hiAPP). In Huntington's disease fibroblast cells, Genistein reduces intracellular mutant huntingtin (mHTT) aggregates and induces degradation of mHTT; in a cellular model of Huntington's disease, Genistein corrects the mutant phenotype through stimulation of autophagy.
Quantity 50 mg
Formula Weight 270.24
Percent Purity >98%
Chemical Name or Material Genistein
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