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Tocris Bioscience™ FRAX 486
Potent PAK inhibitor; brain penetrant and orally bioavailable
Brand: Tocris Bioscience™ 5190/10
224.62 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.
This item is not returnable.
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Description
FRAX 486 is a potent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively). Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons. Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice. Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice. Brain penetrant and orally bioavailable.Specifications
| >98% | |
| FRAX 486 | |
| FRAX 486 |
| 10 mg | |
| 513.39 |
For Research Use Only