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Thermo Scientific™ EZ-Link™ TFP Ester-PEG4-DBCO

An amine reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications. The crosslinker can be used to label a variety of amine containing molecules such as proteins, biomolecules, or small molecules.

222.00€ - 301.00€

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Specifications

Chemical Reactivity Amine-Azide
Cleavable No
Description TFP Ester-PEG4-DBCO
Molecular Weight (g/mol) 714.7
PEGylated Yes
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Thermo Scientific™
C20039 		25 mg
222.00€
25mg
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17621586
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Thermo Scientific™
C20043 		10 x 1 mg
301.00€
Pack of 10
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Description

Description

  • An amine reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications
  • The crosslinker can be used to label a variety of amine containing molecules such as proteins, biomolecules, or small molecules
  • Once a protein or (bio)molecule is DBCO labeled, it can undergo a copper-free azide-alkyne cycloaddition reaction to form a stable triazole linkage with an azide labeled coupling partner
  • Can be used to create diverse conjugates with the biorthogonal coupling between an alkyne and azide (supplied separately)
  • The coupling or crosslinking procedure is typically done in two steps
    • First, a protein or amine containing molecule is labeled with a DBCO group and excess crosslinker is removed
    • Second, an azide containing moiety (prepared independently) is introduced into the same system as the DBCO moiety
    • Labeling occurs under biological conditions without the introduction of any additional reagents such as a copper catalyst
  • Ragent readily dissolves in water-miscible solvents for dilution into aqueous reaction mixtures
  • TFP esters are more hydrolytically stable than NHS esters
Specifications

Specifications

Amine-Azide
TFP Ester-PEG4-DBCO
Yes
Upon receipt store desiccated at -20°C.
Wet Ice
Chemical Labeling
TFP Ester, DBCO
DMF, DMSO
No
No
714.7
17.9 Å
Not determined
EZ-Link™ No-Weigh™
Heterobifunctional
Medium (10 to 30 Å)
Standard, Single-use
Crosslinker
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