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EHT 1864, Tocris Bioscience™

Product Code. 18792724
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Quantity:
10 mg
50 mg
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Description

Potent Rac family inhibitor

Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (KD values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β-amyloid peptide production in vivo.

Chemical Identifiers

CAS 754240-09-0
Molecular Formula C25H29Cl2F3N2O4S
Molecular Weight (g/mol) 581.472
InChI Key LSECOAJFCKFQJG-UHFFFAOYSA-N
Synonym 5-5-7-trifluoromethyl quinolin-4-ylthio pentyloxy-2-morpholinomethyl-4h-pyran-4-one dihydrochloride, 2-morpholin-4-ylmethyl-5-5-7-trifluoromethyl quinolin-4-yl sulfanylpentoxy pyran-4-one;dihydrochloride, 4h-pyran-4-one,2-4-morpholinylmethyl-5-5-7-trifluoromethyl-4-quinolinyl thio pentyl oxy-,hydrochloride 1:2, d0m9er, eht 1864 2hcl, c25h27f3n2o4s.2clh, eht hplc, 2-morpholin-4-ylmethyl-5-5-7-trifluoromethyl quinolin-4-yl sulfanyl pentyl oxy pyran-4-one dihydrochloride, 2-morpholinomethyl-5-5-7-trifluoromethyl quinolin-4-yl thio pentyl oxy-4h-pyran-4-one dihydrochloride, 2-morpholin-4-yl methyl-5-5-7-trifluoromethyl quinolin-4-yl sulfanyl pentyl oxy-4h-pyran-4-one dihydrochloride
PubChem CID 9938202
IUPAC Name 2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one;dihydrochloride
SMILES C1COCCN1CC2=CC(=O)C(=CO2)OCCCCCSC3=C4C=CC(=CC4=NC=C3)C(F)(F)F.Cl.Cl

Specifications

Quantity 50 mg
Formula Weight 581.47
Percent Purity >98%
Physical Form Solid
Chemical Name or Material Rho GTPase Inhibitors
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