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Invitrogen™ Dynabeads™ SARS-CoV-2 Spike
The Dynabeads™ SARS-CoV-2 Spike consists of superparamagnetic beads coupled with a trimeric spike protein. The spike protein is a patented recombinant trimeric structure combining the S1 subunit, including the receptor binding domain (RBD), and the S2 subunit found on the surface of the SARS-CoV-2 virus.
303.00€ - 1280.00€
Specifications
| Certifications/Compliance | ISO 13485 |
|---|---|
| Concentration | 1 mg/mL |
| Content And Storage | The beads are supplied in 0.05 M Tris-buffered saline (TBS) with 0.001% Tween-20 and 0.02% NaN3. Store at 2°C to 8°C. |
| Detection Method | Absorbance at 450 nm |
| Color | Brown |
Description
The Dynabeads SARS-CoV-2 Spike consists of superparamagnetic beads coupled with a trimeric spike protein. The spike protein is a patented recombinant trimeric structure combining the S1 subunit, including the receptor binding domain (RBD), and the S2 subunit found on the surface of the SARS-CoV-2 virus. The virus spike protein binds to human host cells via the angiotensin-converting enzyme 2 (ACE2) receptor to initiate virus attachment, as well as to antibodies produced in the body as a response to SARS-CoV-2 infection.
Dynabeads SARS-CoV-2 Spike features include:
• Fast SARS-CoV-2 antibody binding kinetics
• Dynabeads-facilitated automation (limited hands-on time)
• Also available in SARS-CoV-2 ELISA kits
This Dynabeads SARS-CoV-2 Spike is also included in our enzyme‐linked immunosorbent assay (ELISA) kits designed to detect and quantify the level of human SARS-CoV-2 IgG (add link to #18000D), IgM (add ink to #18010D), and Total Ig (add link to #18020D) antibodies from serum and plasma samples. These kits can be used manually with a DynaMag-96 magnet or in an automated fashion using a KingFisher instrument. The magnetic beads significantly improve the binding kinetics to cut the ELISA incubation time in half (45 minutes) compared to the more conventional plate-based ELISAs (90 minutes).
Since the spike protein binds host cells to initiate the entrance of SARS-CoV-2 virus into the epithelial cells of the lungs via ACE2, the beads may also be used for isolation of ACE2+ cells or for ACE2 protein purification.
Specifications
| ISO 13485 | |
| The beads are supplied in 0.05 M Tris-buffered saline (TBS) with 0.001% Tween-20 and 0.02% NaN3. Store at 2°C to 8°C. |
|
| Brown | |
| Magnetic Polystyrene | |
| KingFisher™ Flex or Apex Instruments, DynaMag™-96 Side Skirted, Magnetic 96-Well Separator, ELISA Plate Reader (450 nm) | |
| Dynabeads™ magnetic beads | |
| 2.7 μm |
| 1 mg/mL | |
| Absorbance at 450 nm | |
| Isolation of SARS-CoV-2 Cells | |
| SARS-CoV-2 Spike Protein Magnetic Beads | |
| Yes, on KingFisher™ Flex or Apex instruments | |
| Wet ice (2° to 8°C) |
For research use only. Not for use in diagnostic procedures.