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CGP 57380, Tocris Bioscience™

Product Code. 18084712
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Quantity:
1 mg
10 mg
50 mg
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Description

Selective inhibitor of Mnk1

Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 μM) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 μM) and inhibits LPS-induced TNFα expression in macrophages.

Chemical Identifiers

CAS 522629-08-9
Molecular Formula C11H9FN6
Molecular Weight (g/mol) 244.233
InChI Key UQPMANVRZYYQMD-UHFFFAOYSA-N
Synonym mnk1 inhibitor, n3-4-fluorophenyl-1h-pyrazolo 3,4-d pyrimidine-3,4-diamine, 4-amino-5-4-fluoroanilino-pyrazolo 3,4-d pyrimidine, d0a7fq, cgp hplc, n-4-fluorophenyl-3h-pyrazolo 3,4-d pyrimidine-3,4-diamine, 3-n-4-fluorophenyl-1h-pyrazolo 3,4-d pyrimidine-3,4-diamine, 3-n-4-fluorophenyl-2h-pyrazolo 3,4-d pyrimidine-3,4-diamine, n3-4-fluorophenyl-1h-pyrazolo-3,4-d pyrimidine-3,4-diamine, n3-4-fluorophenyl-2h-pyrazolo 3,4-d pyrimidine-3,4-diamine
PubChem CID 11644425
IUPAC Name 3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
SMILES C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F

Specifications

Quantity 1 mg
Formula Weight 244.23
Percent Purity >98%
Chemical Name or Material CGP 57380
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