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Invitrogen™ CellSensor™ AP-1-bla ME-180 Cell Line
CellSensor™ AP-1-bla ME-180 Cell Line
Brand: Invitrogen™ K1661
This item is not returnable.
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Description
The CellSensor™ AP-1-bla ME-180 Cell Line contains a beta-lactamase reporter gene under control of the AP-1 response element stably integrated into ME-180 cells. The cell line was created through FACS sorting of cells responsive to stimulation of the AP-1 pathway with Epidermal Growth Factor (EGF). This cell line was validated for DMSO tolerance, stimulant incubation time, substrate loading conditions, Z' and EC50 concentration of Epidermal Growth Factor. The AP-1-bla ME-180 Cell Line responds to agonist treatment as expected from the literature and can be adapted for high-throughput screening for agonists or antagonists of the AP-1 pathway with compound libraries. Candidate drugs can also be tested for dose response against this cell line. Academic and non-profit customers, please inquire for special pricing.
Specifications
| Cell-based beta lactamase reporter gene | |
| CellSensor™ Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use. | |
| 1 vial | |
| Cell Line | |
| CellSensor™ |
| Dividing Cells | |
| CellSensor™ | |
| EGFR, ERK1/2, p38, MEK, MAPK pathway, c-MET, JNK, RON, RAF | |
| ME-180 | |
| Signaling Pathway |
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Product Title
For Research Use Only. Not for use in diagnostic procedures.
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