Argos Technologies™ Cell-Line Adhere Bioreactor Flask

Description

• These bioreactor flasks are viable in vitro alternatives to using mouse ascites, standard cell culture, or tissue culture products
• Bioreactors utilize innovative membrane technology to separate the cell cultivation area from the media chamber
• Cells and cellular-secreted products with a MWCO over 10kD are retained between two non-cytotoxic membranes
• The upper semi-permeable membrane allows continuous nutrient diffusion and waste elimination
• The lower membrane provides direct oxygenation and ensures optimum gas exchange
• Separate ports give access to either media or cell cultivation chamber allowing easy change of expended medium without interference of cell growth, function, or gas exchange
• Developed for the expression of biomolecules in anchorage dependent cell lines
• The observed product concentrations in the cell compartment are in the range of 1-5 mg/ml and are often several hundred times higher than what is obtained in either roller bottles or tissue culture flasks with the same cell type
• Ideal for use with CHO, BHK, HEP2 or any other adherent cell line, CELLine Adhere is available in a one liter format
• The flask is reusable and greatly reduces the downstream processing cost of concentration and purification
• Serum usage is also reduced as a result of the compartmentalized chambers in the flask resulting is a low cost bioreactor for the production of expressed biomolecules