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Celastrol, Tocris Bioscience™

Product Code. 18712564
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Inhibits TNF-α-induced NF-κB activation

Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM).

Chemical Identifiers

CAS 34157-83-0
Molecular Formula C29H38O4
Molecular Weight (g/mol) 450.62
MDL Number MFCD03424073
InChI Key KQJSQWZMSAGSHN-JJWQIEBTSA-N
Synonym celastrol, tripterine, tripterin, 2r,4as,6as,12br,14as,14br-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid, triterpene, celastrol, celastrus scandens, unii-l8gg98663l, 3-hydroxy-24-nor-2-oxo-1 10 ,3,5,7-friedelatetraen-29-oic acid, 2r,4as,6ar,6as,14as,14br-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid, d:a-friedo-24-noroleana-1 10 ,3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, 20alpha
PubChem CID 122724
ChEBI CHEBI:63959
IUPAC Name (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
SMILES CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O

Specifications

Quantity 10 mg
Formula Weight 450.61
Percent Purity >99%
Chemical Name or Material Celastrol
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