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BAY 60-6583, Tocris Bioscience™

Product Code. 18053862
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Quantity:
10 mg
50 mg
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Description

Potent A2B receptor agonist; cardioprotective

Potent adenosine A2B receptor agonist (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2A and A3 receptors. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia. Exhibits ERK1/2-biased agonism.

Chemical Identifiers

CAS 910487-58-0
Molecular Formula C19H17N5O2S
Molecular Weight (g/mol) 379.438
InChI Key ZTYHZMAZUWOXNC-UHFFFAOYSA-N
Synonym 2-6-amino-3,5-dicyano-4-4-cyclopropylmethoxy phenyl pyridin-2-yl sulfanyl acetamide, d0he1p, bay hplc, 2-6-amino-3,5-dicyano-4-4-cyclopropylmethoxy phenyl-2-pyridinyl thio-acetamide, acetamide, 2-6-amino-3,5-dicyano-4-4-cyclopropylmethoxy phenyl-2-pyridinyl thio
PubChem CID 11717831
IUPAC Name 2-[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylacetamide
SMILES C1CC1COC2=CC=C(C=C2)C3=C(C(=NC(=C3C#N)SCC(=O)N)N)C#N

Specifications

Quantity 10 mg
Formula Weight 379.44
Percent Purity >98%
Chemical Name or Material BAY 60-6583
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